The head coach has had to contend with a number of injuries and has rejigged his pack as he looks to get the campaign back on track following the defeat by Wales in Cardiff.
There is a first Scotland start for Rory Darge who is picked at blindside flanker. Sam Skinner, who played at six against the Welsh, moves into the second row to replace the injured Jonny Gray.
Matt Fagerson, who suffered a blow to his foot in Cardiff, also drops out, with Magnus Bradbury slotting in at No 8. Bradbury featured as a sub in the win over England and the defeat in Cardiff.
The third personnel change is in the front row, with Zander Fagerson returning to the starting line-up at tighthead prop in place of WP Nel who drops to the bench.
Saturday’s third round match kicks off 2.15pm and is live on BBC One.
13. Chris Harris
A mainstay in the Scotland backline. Photo: Craig Williamson - SNS Group / SRU
14. Darcy Graham
Was the stand-out Scotland performer in loss to Wales. Photo: Craig Williamson - SNS Group / SRU
15. Stuart Hogg
Captain will win his 91st Scotland cap. Photo: Craig Williamson - SNS Group
16. The replacements
16. George Turner , 17. Oli Kebble (pictured), 18. WP Nel, 19. Jamie Hodgson, 20. Nick Haining, 21. Ben White, 22. Blair Kinghorn, 23. Mark Bennett. Photo: Craig Williamson - SNS Group / SRU