The head coach has had to contend with a number of injuries and has rejigged his pack as he looks to get the campaign back on track following the defeat by Wales in Cardiff.
There is a first Scotland start for Rory Darge who is picked at blindside flanker. Sam Skinner, who played at six against the Welsh, moves into the second row to replace the injured Jonny Gray.
Matt Fagerson, who suffered a blow to his foot in Cardiff, also drops out, with Magnus Bradbury slotting in at No 8. Bradbury featured as a sub in the win over England and the defeat in Cardiff.
The third personnel change is in the front row, with Zander Fagerson returning to the starting line-up at tighthead prop in place of WP Nel who drops to the bench.
Saturday’s third round match kicks off 2.15pm and is live on BBC One.
9. Ali Price
Scrum-half selected for his 49th Scotland appearance. Photo: Craig Williamson - SNS Group / SRU
10. Finn Russell
Racing 92 stand-off is named as vice-captain against France. Photo: Craig Williamson - SNS Group / SRU
11. Duhan van der Merwe
Last season’s top try-scorer in the Six Nations is still looking to get off the mark in this season’s competition. Photo: Craig Williamson - SNS Group / SRU
12. Sione Tuipulotu
Retains his place at inside centre after decent showing in Cardiff. Photo: Craig Williamson - SNS Group