The duo will be looking to follow up their previous wins in the Europa League group stage with another three points to keep the pressure on the top two in each group as they seek progression to the knockout stages.
Celtic are in Hungary to face Ferencvaros, while Rangers are against Brondby in the Danish capital of Copenhagen.
Both teams defeated their opposition last month.
Celtic and Rangers will know that if they finish third in the group they will have the consolation of the Conference League.
On the domestic scene, the weekend's action gets underway on Friday night as Edinburgh City welcome Albion Rovers.
With it now being November, clubs will be looking at contract talks with those players who are on expiring deals.
Scroll down and click through for all the latest from around the SPFL and Scottish football.
5. Musonda to become a free agent
Former Celtic loanee Charly Musonda revealed he will be a free agent at the end of the season. The Belgian hasn’t played first-team football since being on loan to Vitesse Arnhem in 2019 before a knee injury ruled him out for the season. He said: "Enjoying the final ride, while training and slowly getting ready for what lies ahead, with continued faith and optimism." (Instagram) Photo: SNS Group Craig Foy
6. Ryan and Ryan to return
Steven Gerrard is set to welcome back two key stars. Ryan Kent has missed a chunk of this season due to a hamstring injury, while Ryan Jack hasn’t played since February. Both have been training and the former could face Brondby in the Europa League tonight, while the latter has a chance of playing at the weekend. (Daily Record) Photo: Ross MacDonald - SNS Group
7. Dunfermline chairman Ross McArthur to step down
Dunfermline Athletic have revealed chairman Ross McArthur will stand down at the end of the season. He has been on the board at East End Park for seven years but has made the decision “following abhorrent personal abuse and attacks to which he was subjected”. (Dunfermline statement) Photo: SNS Group Paul Devlin
8. Celtic need Rogic competition
Celtic have been tipped to sign competition for Tom Rogic in midfield. Ex-Rangers star Alan Hutton reckons Ange Postecoglou’s side can’t rely on the “same player week after week”. He said: “They need to change it up, especially if they want to win the league and really go for it in European competitions.” (Football Insider) Photo: Ross Parker - SNS Group