New arrival Joe Hart has been handed a debut in goals while Kyogo Furuhashi has also been given his first start after making his debut off the bench in the weekend defeat to Hearts.
Another big call from the Greek-Australian coach sees Odsonne Edouard dropped to the bench with Furuhashi set to lead the attack.
Here is the Celtic starting XI for the big match against the Czech side:
9. AMC - David Turnbull
The former Motherwell man retains his starting berth in the number 10 role Photo: Ross Parker - SNS Group
10. AMR - Liel Abada
The Isreali winger opened his account for Celtic against FC Midtjylland Photo: Craig Williamson - SNS Group
11. FC - Kyogo Furuhashi
A first start for the new Japanese signing who looks set to lead the line with Odsonne Edouard dropped to the bench Photo: Craig Williamson - SNS Group
12. Substitutes
Joining Eduoard on the Celtic bench are Barkas, Bain, Ajeti, Christie, Rogic, Urhoghide, Robertson, Murray, Montgomery and Welsh. Photo: Ross Parker - SNS Group